International Workshop – Complement system: rare diseases and targeted therapies

International Workshop

Complement system:
rare diseases and targeted therapies

Palermo
October 13th – 14th, 2023

Rationale

The renin-angiotensin system with its pro and anti-inflammatory effects, the complement system with C1 inhibitor that inhibits components of the kallikrein-kinin system (KKS), such as activated FXII, FXI and plasma kallikrein, as well plasmin affecting the fibrinolytic system; the coagulation and the KKS, tightly interlinked with the contact system, which is integral to the intrinsic pathway of coagulation (FXI) and thrombus formation; each of them consist of a large number of distinct plasma and membrane-bound proteins and receptors that can be activated through proteolytic cascades. Notably, all systems are excessively activated during inflammation, they have potent pro-inflammatory and prothrombotic effects and they increase vascular permeability, leading to edema. Although the dysregulation of each protein system is involved in the pathogenesis of common disorders, only a few rare diseases such as hereditary angioedema, paroxysmal nocturnal hemoglobinuria, atypical uremic hemolytic syndrome, C3 glomerulopathies, rare coagulopathies, are approved for clinical treatment targeting renin-angiotensin, complement coagulation and KKS. The diagnosis and the treatment of these rare diseases are a challenge for health system because it is necessary to improve basic and clinical knowledge and management skills in order to offer the best response to patient’s needs. In our workshop we would love to discuss the role of these complex plasma protein systems in disease pathogenesis and then share future pharmacological strategies to treat rare and common diseases with plasma contact factors and complement targeted therapies.

In order to achieve the best results within our workshop, it is of fundamental importance that everyone is an active and responsible part in our job project and in the sharing of final common choices.

ITACA Board

Mauro Cancian, Padova
President

Andrea Zanichelli, Milano
Vice President, Treasurer

Francesco Arcoleo, Palermo
Secretary

Vincenzo Montinaro, Acquaviva delle Fonti (BA)
Massimo Triggiani, Salerno
Counselors

Scientific Coordinators

Prof. Francesco Arcoleo
Director of the Unit of Clinical Pathology and Immunology
Ospedale Villa Sofia – Cervello, Palermo

Dr. Pietro Accardo
Regional Reference Center Rare Diseases of the Immune System and Angioedema
Haemostasis and Thrombosis Center
Ospedale Villa Sofia – Cervello, Palermo

Faculty

Pietro Accardo, Palermo
Francesco Arcoleo, Palermo
Gianluigi Ardissino, Milano
Roberta Bulla, Trieste
Mauro Cancian, Padova
Pierpaolo Coni, Cagliari
Davide Firinu, Cagliari
Claire Harris, Newcastle upon Tyne (UK)
Maurizio Margaglione, Foggia
Vincenzo Montinaro, Acquaviva delle Fonti (BA)
Paul Morgan, Cardiff (UK)
Rosario Notaro, Firenze
Santiago Rodriguez de Cordoba, Madrid (ES)
Riccardo Senter, Padova
Massimo Triggiani, Salerno

General information

Official language • English

Venue • NH Hotel Palermo – Foro Italico, 22/B – 90133 Palermo

CME • The Workshop will be included in the Italian National program of Continuing Medical Education (CME), for the profession of Psychologist and Medical Doctor with the following specialties: Nephrologists, Molecular Biology, Genetics, Allergology, Internal Medicine, Haematology, Pathology.
To obtain the CME certificate participants must attend 90% of the workshop and correctly answer to 75% of the learning assessment questionnaire.